Defeat all bosses except Centurion using Rebecca.
Finish the game without saving.
Obtain all weapons.
Put on Team Wesker costume.
Kill 50 enemies with the Death Stare at full charge.
Change into a costume.
Finish the game without using a First-Aid Spray.
Finish the game without using a recovery item (including Green Chemicals).
Finish the game with rank S.
Finish the game without combining herbs.
Finish Leech Hunter with rank A.
Defeat all enemies in Leech Hunter.
Defeat an enemy with a knife.
Defeat Mimicry Marcus for the first time only using a knife.
Play Leech Hunter.
Finish Leech Hunter with rank E or above.
Defeat Queen Leech.
Complete the treatment plant.
Read all files.
Obtain all keys and use them all.
Defeat the Proto Tyrant.
Complete the factory.
Fight off the Proto Tyrant.
Complete the laboratory.
Shoot down a Hunter or an Eliminator while they are jump attacking in the air.
Defeat 16 bats in the church.
Defeat Infected Bat.
Get picked up by the Infected Bat.
Complete the training facility.
Combine every type of herb with each other.
Play the piano using Rebecca.
Defeat an enemy by burning them.
Defeat Mimicry Marcus with a Molotov Cocktail or a Napalm Grenade.
Create a Custom Handgun.
Use a Green Chemical.
Try to push something heavy with Rebecca.
Defeat a zombie by stomping on them.
Destroy a zombie's legs.
Create a Molotov Cocktail.
Attack an enemy to save your partner who is grappling with that enemy.
Defeat Centurion.
Complete the train.
Defeat an enemy with a critical-hit headshot.
Defeat Stinger.
Break free of a Cerberus while they are biting you or trying to push you down.
Collect all of only one color of Leech Charms.
Finish the game on Hard difficulty.